Emergence of another variant like Omicron or Delta unlikely: Virologist

Noted virologist Dr T Jacob John has said that unless India sees four weeks of low and stable numbers of COVID-19 cases with only minor fluctuations, the disease cannot be considered to be entering the endemic stage.

Dr John said that the endemic phase of COVID-19 is expected to last for many months and it is “most unlikely” that another variant with higher transmissibility than Omicron and greater virulence than Delta will emerge.

The third wave of COVID-19 in India has been plateauing. The number of cases started declining after January 21, when 3,47,254 infections were reported.

As of Tuesday, India’s daily COVID-19 cases have remained below one lakh for nine consecutive days.

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“When case numbers in a community are plotted on graphs, the pattern of rise, peak and fall represent epidemic (or outbreak) and case numbers as a horizontal steady state are called endemic. When an epidemic pattern repeats, we call each a wave. So unless we see four weeks of low and stable numbers with only minor fluctuations, we cannot call the valley as endemic just as yet,” Dr John told PTI.

“The Omicron wave is receding so fast that in a few more days we may reach the valley, but we will wait for four weeks to be sure of endemic prevalence,” Dr John said.

Asked what can be expected in the coming months, the former director of the Indian Council for Medical Research’s Centre of Advanced Research in Virology said that it cannot be predicted, but only speculated.

“My intelligent guess: we will slip into an endemic phase for many months without any more waves with Alpha, Beta, Gamma, Delta or Omicron. It will be most unlikely that yet another variant that will spread faster than Omicron and more efficient in immune evasion than Delta or Omicron will emerge,” he said.

He, however, didn’t rule out the possible emergence of a “weird” variant.

“However, just as Omicron surprised us, another weird variant could surprise us yet again,” he said, adding that during the endemic phase, some will be infected, sick, hospitalised and even die.

Dr John cautioned that without high vaccination coverage, small waves may recur perhaps once a year or once in a few years, modulated by vaccination coverage in all age groups.

“We have vaccines. For all current vaccines, two doses plus a booster are the minimum schedule. Additional boosters will be decided on future information,” he added.

Dr Chandrakant Lahariya, a physician-epidemiologist and executive director of the Delhi-based Foundation for People-Centric Health Systems, said that it is of limited relevance from the perspective of the general public whether COVID-19 has become endemic in India or not.

“This is a discourse which will continue for a while. From the perspective of interventional epidemiology, which focuses on operational solutions, India soon, in a few weeks, would be at a stage where everything should be fully open. That point onwards, people would have to adapt to the new way of living with the virus depending upon their level of risk. But because of COVID-19 nothing should be stopped,” Dr Lahariya told PTI.

He said that to facilitate a smooth transition, there is a need to start a socio-political discourse on what is normal and how to ensure maximum safety.

“This would mean improved ventilation in closed spaces, additional protection for high-risk populations, phasing out of the mask mandate – first for children and then for adults. Unless this societal discourse is started, things would be delayed,” Dr Lahariya added.

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He said that pandemics end with a socio-political consensus to arrive at an agreement of what a society would like to call endemic.

“What is important to remember is that pandemics start with a pathogen. In this case, due to the virus. They end with a socio-political consensus to arrive at an agreement of what a society would like to call endemic. Therefore, when a setting reaches endemicity is not going to be a binary of pandemic or endemic,” Dr Lahariya said.

(With inputs from agencies)